Labels:text | screenshot | black and white | black | font | document OCR: ular cyclic Many receptors alter the level of intrace ct directly nucleotides. Such receptors do not inter gh an with the cyclase enzymes but work throw sine intermediate protein which binds guand ing protein, 5'-triphosphate (GTP), called a GTP-bind subset of or more simply, a G-protein. Recently, a have been GH-secreting human pituitary tumours ns of tivity in discovered, which carry somatic mutatic G-protein a-chains that inhibit GTPase a on of somatotroph cells. The resulting activati enoma adenylate cyclase within GH-secreting a the cell to cells bypasses the normal requirement o nomous, be activated by GHRH and thus, it is aut te tumour Such an oncogenic mutation may prom ion of growth by producing an autonomous ac iferative proteins that normally transmit the pro signals initiated b ...
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